DNA molecule encoding a variant alpha-2B-adrenoaceptor protein and uses thereof
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United States of America Patent
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Issued Date -
Aug 5, 2004
app pub date -
Mar 26, 2004
filing date -
Oct 22, 1999
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
This invention relates to a DNA sequence comprising a nucleotide sequence encoding a variant .alpha..sub.2B-adrenoceptor protein and to the variant .alpha..sub.2B-adrenoceptor protein as well as a method for screening a subject to determine if the subject is a carrier of a variant gene that encodes the variant .alpha..sub.2B-adrenoceptor protein. This invention also relates to a method for treating a mammal suffering from vascular contraction of coronary arteries, the method comprising the step of administering a selective .alpha..sub.2B-adrenoceptor antagonist to the mammal. This invention further relates to transgenic animals comprising a human DNA molecule encoding human .alpha..sub.2B-adrenoceptor protein or the variant .alpha..sub.2B-adrenoceptor protein.
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