Controlled absorption of admixed thyroid hormone formulations
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United States of America Patent
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Issued Date -
Aug 5, 2004
app pub date -
Nov 5, 2003
filing date -
Nov 5, 2002
priority date (Note) -
Abandoned
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Abstract
The invention relates to admixtures of the thyroid hormones and derivatives thereof. These admixtures, particularly L-thyroxine (T4) and liothyronine (T3), produce steady state or near steady state serum levels of T3. When admixed in the appropriate ratio of T4 to T3, blood levels of T3 hormone are maintained at a steady state for an extended period of time independent of the need for control release excipients. The change in the kinetics of T3 absorption is controlled by the addition of T4 to T3.
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