Cellular gene targets for controlling cell growth
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United States of America Patent
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Issued Date -
Sep 2, 2004
app pub date -
May 19, 2003
filing date -
May 17, 2002
priority date (Note) -
Abandoned
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Abstract
A method of identifying a compound that induces apoptosis in a cell is disclosed. The method includes contacting the cell with a putative apoptosis-inducing compound and determining whether the compound inhibits a target selected from the group consisting of APLP2, ENSA, FBN2, FIBL-6, PRNP, STRN4, XPR1, SLC5A6, SLC31A1, GFER, and PCTK1. Also disclosed are methods for inducing apoptosis in a cell by inhibiting one of the targets. The invention further includes methods for the diagnosis of a tumor that include determining the level of one of the targets as a marker in a patient sample, the level of the marker being indicative of the presence of tumor cells.
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