Compounds and methods for modulating functions of nonclassical cadherins
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United States of America Patent
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Jan 13, 2009
Grant Date -
Sep 9, 2004
app pub date -
Nov 14, 2003
filing date -
Nov 14, 2002
priority date (Note) -
Expired
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Abstract
Modulating agents and methods for enhancing or inhibiting nonclassical cadherin-mediated functions, such as atypical or desmosomal cadherin-mediated functions, are provided. The modulating agents comprise at least a tryptophan-containing cell adhesion recognition sequence of an atypical and/or desmosomal cadherin, a conservative analogue or peptidomimetic thereof, or an antibody or fragment thereof that specifically binds to such a cell adhesion recognition sequence. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by cadherins and/or other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, pharmaceutically active substance and/or support material.
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