Controlled-release compositions containing opioid agonist and antagonist
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United States of America Patent
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Issued Date -
Sep 9, 2004
app pub date -
Dec 29, 2003
filing date -
Feb 8, 2000
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Controlled-release dosage forms containing an opioid agonist; an opioid antagonist; and a controlled release material release during a dosing interval an analgesic or sub-analgesic amount of the opioid agonist along with an amount of said opioid antagonist effective to attenuate a side effect of said opioid agonist. The dosage form provides analgesia for at least about 8 hours when administered to human patients. In other embodiments, the dose of antagonist released during the dosing interval enhances the analgesic potency of the opioid agonist.
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