Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
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United States of America Patent
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Aug 20, 2013
Grant Date -
Sep 30, 2004
app pub date -
Mar 5, 2004
filing date -
Feb 2, 2001
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Abstract
Compositions and methods are provided for forming tissue-adherent hydrogels using substantially dry precursors. The dehydrated precursors are premixed prior to in situ therapy and utilize naturally-occurring body fluids as an aqueous environment that initiates transformation, which causes dissolution and nearly simultaneous crosslinking of the precursors, thus forming an insoluble hydrogel implant. The dehydrated precursor-based hydrogels may be used as sealants for fluid leaks from tissue, as adherent drug delivery depots, as means for augmenting and/or supporting tissue, and as means for serving a variety of other useful medical and surgical purposes.
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