Non-invasive prenatal genetic diagnosis using transcervical cells
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United States of America Patent
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Issued Date -
Oct 7, 2004
app pub date -
Apr 3, 2003
filing date -
Apr 3, 2003
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
A method is provided for determining the gender and/or chromosomal abnormality, e.g. chromosomal aneuploidy of a fetus comprising identifying fetal cells in a transcervical cell sample obtained from a pregnant woman, for example with an antibody specific to the HLA-G antigen expressed only by extravillous trophoblast cells, and then subjecting the identified fetal cells to fluorescence in situ hybridization (FISH) with one or more probes for detecting the sex of the fetus or a chromosomal abnormality such as a monosomy, a trisomy or a polyploidy, e.g. triploidy.
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