Apparatus for the automated synthesis of polynucleotides
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United States of America Patent
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Issued Date -
Nov 11, 2004
app pub date -
May 6, 2003
filing date -
May 6, 2003
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The invention provides an apparatus for maintaining a closed continuous anhydrous system for automated polynucleotide synthesis, having a) a plurality of moisture-resistant reagent containers, b) a dry box capable of forming a seal over a synthesis platform of an automated polynucleotide synthesizer, c) moisture-resistant tubing connecting the reagent containers to the dry box, d) a reagent gas feed connecting the reagent containers to a gas, where the gas pressurizes the reagent containers, and e) a digital gas regulator connected to the reagent gas feed, where the gas regulator maintains constant pressure in the reagent containers.
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