Production of host cells containing multiple integrating vectors by serial transduction
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United States of America Patent
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Issued Date -
Nov 25, 2004
app pub date -
Jan 16, 2004
filing date -
Jul 3, 2000
priority date (Note) -
Abandoned
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Abstract
The present invention relates to the production of proteins in host cells, and more particularly to host cells containing multiple integrated copies of an integrating vector comprising an exogenous gene and methods of making such host cells by serial transduction or transfection. The present invention further provides methods of expressing increased levels of protein in host cells using such vectors.
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