Vaccine preparations
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United States of America Patent
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Issued Date -
Dec 2, 2004
app pub date -
Apr 6, 2004
filing date -
Apr 7, 2003
priority date (Note) -
Abandoned
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Abstract
Live or killed preparations of attenuated mutant Neisseria bacteria, e.g. N. meningitidis, have the following mutations: (a) an auxotrophic attenuating mutation, e.g. AroA or AroB mutation, (b) a capsule mutation, e.g. synX or galE mutation, and also (c) a mutation which reduces bacterial recombination or exogenous DNA uptake, such as RecA and/or comA mutations. The mutants and their preparations can be used in vaccine compositions.
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