Stimulation of thymus for vaccination development
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United States of America Patent
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Issued Date -
Dec 2, 2004
app pub date -
Dec 30, 2003
filing date -
Apr 15, 1999
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present disclosure provides methods for enhancing the response of a patient's immune system to vaccination. This is accomplished by reactivating the thymus. Optionally, hematopoietic stem cells, autologous, syngeneic, allogeneic or xenogeneic, are delivered to increase the speed of regeneration of the patient's immune system. In one embodiment the hematopoietic stem cells are CD34.sup.+. The patient's thymus is reactivated by disruption of sex steroid mediated signaling to the thymus. In one embodiment, this disruption is created by administration of LHRH agonists, LHRH antagonists, anti-LHRH receptor antibodies, anti-LHRH vaccines or combinations thereof.
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