Treatment of heart rhythm disturbances with N6-substituted-5'-(N-substitut-ed) carboxamidoadenosines
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United States of America Patent
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Issued Date -
Dec 2, 2004
app pub date -
Jun 29, 2004
filing date -
Nov 23, 1999
priority date (Note) -
Abandoned
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Abstract
The present invention discloses a method for treating heart rhythm disturbances in a mammal in need thereof by the administration of N.sup.6-substituted-5'-(N-substituted)carboxamidoadenosines. More particularly, the invention is directed to a method for treatment of heart rhythm disturbances in a mammal that would benefit from the induction of negative dromotropic and/or negative chronotropic actions, comprising the administration to said mammal an effective amount of a compound of the Formula: 1 or a pharmaceutically acceptable salt or ester thereof; wherein R.sub.1 is C.sub.3-7 secondary alkyl, or C.sub.3-8 cycloalkyl; and R.sub.2 is C.sub.1-4 alkyl or C.sub.3-5 cycloalkyl The invention is also directed to novel dosage forms comprising said compounds.
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