Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility
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United States of America Patent
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Issued Date -
Dec 9, 2004
app pub date -
Jun 5, 2003
filing date -
Jun 5, 2003
priority date (Note) -
Abandoned
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Abstract
Methods are provided that for producing aqueous formulations of pharmaceutical agents having low aqueous solubility. The methods also provide a simple means of producing the formulation as a sterile product. The drug is physically entrapped by a spatially stabilized matrix comprising a hydrophilic or hydrophilic-hydrophobic block polymer, without being covalently bound to the polymer. The drug formulation is a nanoparticle or sub-nanoparticle in size. In a preferred embodiment the nanoparticles are anisotropic, being much longer than they are wide.
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