Sustained release hgf hydrogel preparations
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United States of America Patent
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Issued Date -
Dec 16, 2004
app pub date -
Feb 11, 2004
filing date -
Jul 18, 2001
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention relates to a sustained release HGF gelatin hydrogel preparation containing a gelatin hydrogel obtained by crosslinking a gelatin having the following properties: (1) an acidic gelatin obtained from collagen by an alkali hydrolysis treatment, (2) a molecular weight of about 100,000-about 200,000 daltons under non-reducing conditions of SDS-PAGE, (3) an isoelectric point of about 5, and (4) a zeta potential in an aqueous solution of about -15 to about -20 mV, and a hepatocyte growth factor (HGF), and an angiogenesis and vasculogenesis promoter and a therapeutic agent for arterial diseases, which contain this preparation.
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