Active drug delivery in the gastrointestinal tract
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United States of America Patent
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Issued Date -
Dec 30, 2004
app pub date -
May 3, 2004
filing date -
Jan 29, 2003
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Apparatus for drug administration is provided, including an ingestible capsule, which includes a drug, stored by the capsule, and an environmentally-sensitive mechanism, adapted to change a state thereof responsively to a disposition of the capsule within a gastrointestinal (GI) tract of a subject. The capsule further includes first and second electrodes, and a control component, adapted to facilitate passage of the drug, in response to a change of state of the environmentally-sensitive mechanism, through an epithelial layer of the GI tract by driving the first and second electrodes to apply a 'low intensity time-varying' (LITV) signal.
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