N-TRADD active site and uses thereof
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United States of America Patent
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Dec 2, 2008
Grant Date -
Jan 6, 2005
app pub date -
Jul 20, 2004
filing date -
Apr 6, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention relates to the three dimensional solution structure of the N-terminal domain of TNFR-1 associated death domain protein ('N-TRADD'), as well as the identification and characterization of a C-TRAF2 binding active site of N-TRADD. Also provided for by the present invention are methods of utilizing the three dimensional structures for the design and selection of potent and selective inhibitors of TNF signaling pathways.
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