Mammalian cell culture processes for protein production
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United States of America Patent
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Jun 2, 2009
Grant Date -
Jan 27, 2005
app pub date -
Dec 18, 2003
filing date -
Dec 23, 2002
priority date (Note) -
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Abstract
The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, preferably, but not limited to, fed-batch cell cultures. In one aspect, the methods comprise at least two temperature shifts performed during the culturing period, in which the temperature is lower at the end of the culturing period than at the time of initial cell culture. Throughout their duration, the culturing processes of the invention involving two or more downward shifts in temperature sustain a high viability of the cultured cells, and can yield an increased end titer of protein product, and a high quality of protein product, as determined, e.g., by sialic acid content of the produced protein. In another aspect, the methods comprise the delayed addition of polyanionic compound during the culturing period. The delayed addition of polyanionic compound sustains a high viability of the cultured cells, and can extend the growth phase, delay the onset of the death phase, and arrest the death phase.
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- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
- BRISTOL-MYERS SQUIBB COMPANY
International Classification(s)
- [Classification Symbol]
- [Patents Count]
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Basch, Jonathan D | East Syracuse, US | 4 | 212 |
Burnett, William V | Fayetteville, US | 5 | 101 |
Joosten, Christoph E | Manlius, US | 5 | 217 |
Lee, Steven S | Manlius, US | 31 | 1026 |
Matlock, Linda | Parish, US | 4 | 212 |
Sakhamuri, Sivakesava | Syracuse, US | 4 | 212 |
Schilling, Bernhard M | Syracuse, US | 6 | 220 |
Zegarelli, Stephen G | North Syracuse, US | 4 | 212 |
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Fee | Large entity fee | small entity fee | micro entity fee |
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Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
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