Compositions and methods relating to the daptomycin biosynthetic gene cluster
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United States of America Patent
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Issued Date -
Feb 3, 2005
app pub date -
Jul 31, 2002
filing date -
Aug 6, 2001
priority date (Note) -
Abandoned
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Abstract
The invention provides nucleic acid molecules comprising all or a part of a daptomycin biosynthetic gene cluster. The daptomycin biosynthetic gene cluster may be derived from Streptomyces, preferably from S. roseosporus. The invention also provides other nucleic acid molecules from S. roseosporus. The invention further provides polypeptides encoded by the nucleic acid molecules, antibodies that specifically bind to the polypeptides, and methods of using the nucleic acid molecules, polypeptides and antibodies to produce daptomycin and other compounds.
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