Methods for sterilizing preparations of digestive enzymes
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United States of America Patent
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app pub date -
May 7, 2004
filing date -
Aug 31, 2001
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Abstract
Methods are disclosed for sterilizing preparations of digestive enzymes to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. These methods involve sterilizing preparations of digestive enzymes, such as trypsin, .alpha.-galactosidase and iduronate-2-sulfatase, with irradiation.
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