Kinase and phosphatase assays
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United States of America Patent
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Sep 1, 2009
Grant Date -
Mar 10, 2005
app pub date -
Jul 29, 2004
filing date -
Jul 29, 2003
priority date (Note) -
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Abstract
Compositions, methods, and kits for detecting and monitoring kinase or phosphatase activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase or phosphatase alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition. Panel assays for determining substrates or modulators of kinase or phosphatase activity are also described.
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