Use of transgenic mice for the efficient isolation of novel human monoclonal antibodies with neutralizing activity against primary HIV-1 strains and novel HIV-1 neutralizing antibodies

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United States of America Patent

APP PUB NO 20050058983A1
SERIAL NO

10628004

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Abstract

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The present invention relates to a novel human antibody, and antigen-binding portion thereof, that specifically binds HIV-1 gp120 protein and that has HIV-1 neutralizing activity. The present invention also relates to a cell line that produces an antibody of this invention. The present invention further relates to a pharmaceutical composition or a kit comprising an antibody or antigen binding portion thereof of this invention. The present invention further relates to a method of using the antibody of this invention to treat a subject with an HIV-1 infection or prevent a subject from getting an HIV-1 infection. The present invention also relates to a novel method of making an antibody of this invention. The method involves using a non-human transgenic animal. The present invention further relates to methods of identifying regions of gp120 for use as HIV-1 vaccine.

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Patent Owner(s)

Patent OwnerAddress
ABGENIX INC6701 KAISER DRIVE FREMONT CA 94555

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Corvalan, Jose R Foster City, CA 17 404
He, Yuxian Forest Hills, NY 4 10
Pinter, Abraham Brooklyn, NY 19 185

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