Synthetic hcv envelope proteins and their use for vaccination
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United States of America Patent
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Issued Date -
Mar 31, 2005
app pub date -
Sep 17, 2004
filing date -
Sep 13, 2001
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention relates to the amino acid and deduced nucleic acid sequence of synthetic E2 proteins comprising a consensus sequence of the most conserved amino acids found in E2 of 77 different HCV 1b isolates worldwide. The invention further relates to a truncated version of the E2 protein lacking HVR1. Another aspect of the present invention concerns a vaccine comprising the E2 proteins.
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