Antibodies and uses thereof
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United States of America Patent
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Issued Date -
Mar 31, 2005
app pub date -
Jun 30, 2004
filing date -
Jun 30, 2003
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention provides antibodies or fragments thereof that bind to cancer cells and is important in physiological phenomena, such as cell rolling and metastasis. Therapeutic and diagnostic methods and compositions using such antibody fragments thereof are also provided. The methods and compositions according to the present invention can be used in targeting therapeutic agents and in diagnosis, prognosis, and staging of and therapy for such diseases as cancer, including tumor growth and metastasis, leukemia, auto-immune disease, and inflammatory disease. Also provided is a library of immunoglobulin binding domains having a diverse antigen-binding domain for complementary binding, wherein the library has diversity only in heavy chain CDR3.
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