Novel ester derivatives of buprenorphine and their preparation processes, and long acting analgestic pharmaceutical compositions
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United States of America Patent
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Issued Date -
Apr 7, 2005
app pub date -
Aug 22, 2003
filing date -
Nov 12, 2002
priority date (Note) -
Abandoned
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Abstract
Disclosed herein are novel buprenorphine monocarboxylic ester derivatives and dibuprenorphine dicarboxylic ester derivatives which exert a longer analgesic effect as compared to buprenorphine hydrochloride. Also disclosed are the processes for synthesizing the novel ester derivatives of buprenorphine, and long-acting analgesic pharmaceutical compositions containing a compound selected from buprenorphine base and the novel ester derivatives of buprenorphine.
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