Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof
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United States of America Patent
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Jun 12, 2007
Grant Date -
Apr 21, 2005
app pub date -
Jan 28, 2003
filing date -
Jan 30, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention provides a compound represented by general formula (I): ##STR00001## or pharmaceutically acceptable salts thereof, wherein W is O, S(O).sub.m, CH.sub.2 and the like; R.sup.1 is halogen, lower alkyl, halo-lower alkyl, CN and the like; R.sup.3 is hydrogen and the like; R.sup.4 is hydrogen, halogen, alkyl, halo-lower alkyl, substituted alkyl, aryl, aralkyl, alkoxy, substituted alkoxy, alkanoyl, aroyl, --CONR.sup.7(R.sup.8), --S(O).sub.mR.sup.9, --SO.sub.2NR.sup.7(R.sup.8) and the like; R.sup.5 is hydrogen, halogen, alkyl, substituted alkyl and the like; A is --N(R.sup.6)CO--A.sup.1--COR.sup.10 and the like; pharmaceutical compositions containing them and their uses, which have a high affinity to human thyroid hormone receptors, in particular human thyroid hormone receptor .beta..
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