Genotyping by liquid chromatographic analysis of short nucleic acid fragments

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United States of America Patent

APP PUB NO 20050089850A1
SERIAL NO

10398005

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides genotyping analysis by liquid chromatographic analysis of short nucleic acid fragments. The nucleic acid fragments are amplification products using specifically designed oligonucleotides as primers and target nucleic acids containing nucleotides of interest as templates. The oligonucleotides contain recognition sequences for restriction endonucleases that cleave outside the recognition sequences. The short nucleic acid fragments can be rapidly and reliably analyzed using liquid chromatography, optionally followed by mass spectrometry, and the nucleotides of interest identified.

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Patent Owner(s)

Patent OwnerAddress
KECK GRADUATE INSTITUTE535 WATSON DRIVE CLAREMONT CA 91711

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Galas, David J Claremont, CA 25 1280
Garrison, Lori K Claremont, CA 5 304
Van, Ness Jeffrey Claremont, CA 39 2588

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