Method of treating cancer using dithiocarbamate derivatives
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United States of America Patent
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Issued Date -
May 5, 2005
app pub date -
Aug 20, 2004
filing date -
Sep 8, 1998
priority date (Note) -
Abandoned
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Abstract
The invention encompasses neutral dithiocarbamate metal compounds and methods of treating cancer using such compounds, along with methods for sensitizing AIDS/HIV patients to anti-retroviral therapy by blocking the P-glycoprotein membrane toxin extrusion pump using such compounds. Compounds inhibit the growth of cancer cells of a variety of cell types. A method is presented for using the neutral compounds disclosed herein, amongst other uses disclosed herein, to reduce tumor growth, and to potentiate the effect of other anticancer agents. The invention also encompasses pharmaceutical compositions comprising the neutral compounds and a pharmaceutically acceptable excipient, diluent, solubilizer, solvent, adjuvant or carrier, or a mixture thereof.
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