Solid compositions containing compounds unstable to oxygen and method for stabilization thereof
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United States of America Patent
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Issued Date -
Jun 2, 2005
app pub date -
Jun 9, 2004
filing date -
Dec 19, 2001
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention aims at stabilizing a solid composition containing a nitrogenous fused-heterocycle compound unstable to oxygen to provide a stable pharmaceutical preparation. The stabilization can be attained by keeping the equilibrium moisture content at 10% or above and/or adding ascorbic acid or a salt thereof, by preliminarily applying a film coating free from light blocking agents, or by applying one or more packaging selected from among oxygen-barrier packaging, inert gas replacement packaging, vacuum packaging and sealing packaging with an oxygen absorber.
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