CA6 antigen-specific cytotoxic conjugate and methods of using the same
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United States of America Patent
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Issued Date -
Jun 9, 2005
app pub date -
Jul 21, 2004
filing date -
Jul 21, 2003
priority date (Note) -
Abandoned
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Abstract
Cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the CA6 glycotope. The present invention is also directed to humanized or resurfaced versions of DS6, an anti-CA6 murine monoclonal antibody, and epitope-binding fragments thereof.
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