Method of diagnosing adolescent idiopathic scoliosis and related syndromes
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United States of America Patent
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Issued Date -
Jun 16, 2005
app pub date -
Aug 27, 2004
filing date -
Feb 28, 2002
priority date (Note) -
Abandoned
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Abstract
A method for diagnosing an increased risk for a disease characterized by a dysfunctional melatonin-signaling path-way in an animal comprising detecting the presence or absence of at least one impairment in melatonin-signaling pathway in at least one of the animal's cells, wherein the presence of at least one impairment in melatonin-signaling pathway indicates that the animal possesses an increased risk of developing said disease, and a method of screening for a compound useful in the treatment of a disease characterized by a dysfunctional melatonin-signaling pathway, said method comprising the steps of contacting a candidate compound with at least one cell expressing at least one melatonin-signaling pathway impairment, wherein the candidate compound is selected if said melatoninsignaling pathway impairment is reduced in the presence of the candidate compound as compared to that in the absence thereof.
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Family
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