Composite nanospheres and their conjugates with biomolecules
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United States of America Patent
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Feb 21, 2006
Grant Date -
Jun 23, 2005
app pub date -
Dec 28, 2004
filing date -
Nov 5, 1999
priority date (Note) -
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Abstract
The invention concerns composite nanospheres having a diameter ranging between about 50 and 1000 nm plus or minus 5%, preferably between about 100 and 500 nm plus or minus 5% and advantageously between 100 and 200 nm plus or minus 5%, and comprising an essentially liquid core consisting of an organic phase and inorganic nanoparticles, distributed inside the organic phase, and a skin consisting of at least a hydrophilic polymer derived from the polymerisation of at least one water soluble monomer, in particular N-alkylacrylamide or a N-N-dialkylacrylamide; conjugates derived from said nanospheres; their preparation methods and their uses.
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