Methods for cloning mammals using remodeling factors
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United States of America Patent
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Issued Date -
Jul 7, 2005
app pub date -
Aug 12, 2004
filing date -
Jun 14, 2001
priority date (Note) -
Abandoned
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Abstract
Methods and compositions are provided for remodeling nuclear donor material used in nuclear transfer procedures. By exposing donor chromatin to one or more exogenous remodeling factors, the limited ability of mammalian oocytes to remodel the chromatin of differentiated cells, including fetal and live-born somatic cells, can be increased, resulting in dramatically improved cloning efficiencies.
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