Desensitization of compliment activation using monocyte/macrophage inhibitory compounds
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United States of America Patent
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Issued Date -
Jul 14, 2005
app pub date -
Nov 4, 2004
filing date -
Nov 7, 2003
priority date (Note) -
Abandoned
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Abstract
The present invention relates to methods and compositions designed for the prevention, reduction, treatment, or management of complement activation-related acute hypersensitivity also known as C-mediated pseudoallergy (CARPA) that results from the administration of a medicinal composition including, but not limited to, those compositions in liposomal, micellar, nanoparticle, emulsion, and colloidal formulations. The methods of the invention comprise the administration of an effective amount of one or more therapeutic agents containing one or more active compounds which specifically decreases or inhibits the activity of and/or eliminates or diminishes the amount of macrophages and/or monocytes. In preferred embodiments, the active compound is a bisphosphonate.
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