Tissue engineering scaffolds promoting matrix protein production
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United States of America Patent
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Issued Date -
Jul 21, 2005
app pub date -
Dec 21, 2004
filing date -
Aug 21, 2000
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention provides tissue engineering scaffolds capable of inducing extracellular matrix production by a cell attached to the tissue engineering scaffolds, the tissue engineering scaffolds comprising: a scaffold; a polymer tether covalently coupled to the scaffold; and a TGF-.beta. molecule that is covalently coupled to the polymer tether, wherein the TGF-.beta. molecule is present at a concentration sufficient to elicit production of extracellular matrix by the cell attached to the tissue engineering scaffold without increasing cellular proliferation of the attached cell.
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