Methods and compositions relating to modulating amyloid precursor protein cleavage
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United States of America Patent
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Issued Date -
Aug 4, 2005
app pub date -
Nov 8, 2004
filing date -
Nov 7, 2003
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Abandoned
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Abstract
The invention relates in part assays for identifying and testing compounds that modulate cleavage of amyloid precursor protein (APP). In addition, the invention relates to novel cleavage products of APP. The invention additionally relates to methods and assays for identifying compounds that inhibit acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity. The methods and products of the invention are useful for identifying compounds to prevent and/or treat APP-cleavage associated disorders (e.g. Alzheimer's disease) and are also useful for identifying compounds to prevent and/or treat ACAT-associated disorders.
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