Drug delivery systems and use thereof
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United States of America Patent
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Issued Date -
Aug 11, 2005
app pub date -
Nov 2, 2004
filing date -
May 2, 2002
priority date (Note) -
Abandoned
status (Latency Note)
Importance
Abstract
The invention provides a microsphere formulation for the sustained delivery of an aptamer, for example, an anti-Vascular Endothelial Growth Factor aptamer, to a preselected locus in a mammal, such as the eye. In addition, the invention provides methods for making such formulations, and methods of using such formulations to deliver an aptamer to a preselected locus in a mammal. In particular, the invention provides a method for delivering the aptamer to an eye for the treatment of an ocular disorder, for example, age-related macular degeneration.
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