Non-invasive prenatal genetic diagnosis using transcervical cells

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United States of America Patent

SERIAL NO

11088882

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Abstract

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A non-invasive, risk-free method of prenatal diagnosis is provided. According to the method of the present invention transcervical specimens are subjected to trophoblast-specific immuno-staining followed by FISH, PRINS, Q-FISH and/or MCB analyses and/or other DNA-based genetic analysis in order to determine fetal gender and/or identify chromosomal and/or DNA abnormalities in a fetus. Also provided is a method of in situ chromosomal, DNA and/or RNA analysis of a prestained specimen by incubating the prestained specimen in ammonium hydroxide. Also provided is a method of identifying embryonic cells according to a nucleus/cytoplasm ratio of at least 1:1 and the presence of at least variably condensed chromatin.

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Patent OwnerAddress
MONALIZA MEDICAL LTD11 HASADNA STREET RAANAN 43650

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Amiel, Aliza Ein-Sarid, IL 6 77
Fejgin, Moshe D Tel-Aviv, IL 5 73
Liberman, Meytal Rehovot, IL 3 23

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