Process to prepare semicarbazones' and/or tiosemicarbazones' formulations using cyclodextrins and their derivatives and products obtained by this process
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United States of America Patent
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Issued Date -
Aug 18, 2005
app pub date -
Mar 29, 2005
filing date -
Feb 6, 2002
priority date (Note) -
Abandoned
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Abstract
The preparation of semicarbazone and/or thiosemicarbazone formulations with cyclodextrins and their derivatives and products obtained by this process. The invention is characterized by obtaining inclusion compounds of semicarbazone and/or thiosemicarbazones with cyclodextrins and their derivatives, which were tested in experimental epilepsy models and allowed the reduction of the anticonvulsant dose from 100 mg/kg. This means an improvement in the bioavailability of the compounds in biological systems. These results obtained in animal models make semicarbazones and/or thiosemicarbazones included in cyclodextrins and their derivatives new anticonvulsant candidates. The invention is also characterized by the improved efficacy of semicarbazones and/or thiosemicarbazones included in cyclodextrins and their derivatives in comparison to free components. In addition the present invention is also characterized by the pain killer effect of semicarbazones and thiosemicarbazones. The invention is also characterized by a lowering of the dose necessary for the pain killer effect of semicarbazones and thiosemicarbazones upon inclusion into cyclodextrins.
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