Sampling interface system for in-vivo estimation of tissue analyte concentration
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United States of America Patent
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Issued Date -
Aug 25, 2005
app pub date -
Jan 6, 2005
filing date -
Mar 7, 2003
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Sampling is controlled to enhance analyte concentration estimation derived from noninvasive sampling. Means of assuring that the same tissue sample volume is repeatably sampled are presented, thus minimizing sampling errors due to mechanical tissue distortion, specular reflectance, and probe placement. In a first embodiment of the invention, sampling is controlled using automated delivery of a coupling fluid to a region between a tip of a sample probe and a tissue measurement site in a manner requiring minimal user interaction. In a second embodiment of the invention, sampling is controlled by controlling temperature variations, preferably with a coupling fluid, at a region about the tip of a sample probe and a sample site. In a third embodiment, sampling is procedurally controlled via timing and location of coupling fluid delivery to a sample site.
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