Liposome composition for delivery of therapeutic agents
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United States of America Patent
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Issued Date -
Sep 1, 2005
app pub date -
Jan 13, 2005
filing date -
Jan 15, 2004
priority date (Note) -
Abandoned
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Abstract
A neutral cationic lipid and liposomes prepared from the neutral cationic lipid are described. Liposomes comprised of the lipid are suitable for delivery of a polyanionic compound, such as a nucleic acid. The delivery can be performed in vivo or ex vivo. The neutral cationic lipid, which is neutral in charge at physiologic pH and positively charged at pH values less than physiologic pH, contains a polar head group that imparts solubility of the lipid and permits its packing into a liposomal lipid bilayer.
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