Method of screening cocaine antagonists
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United States of America Patent
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Issued Date -
Sep 8, 2005
app pub date -
Mar 5, 2004
filing date -
Mar 5, 2004
priority date (Note) -
Abandoned
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Abstract
The present invention provides a method of screening for antagonists of cocaine and other abused psychostimulants that exert their effects via the dopamine transporter protein, of therapeutic value in treating psychostimulant addiction. More particularly, the invention provides a method of screening for compounds that prevent inhibition of dopamine transport by an abused psychostimulant, using a mutant dopamine transporter protein. The mutant dopamine transporter protein provides the ability to select compounds that not only inhibit cocaine or other drugs from binding to the protein, but also prevent psychostimulant drugs of abuse from interfering with the protein's ability to transport dopamine across the cell membrane.
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