US Patent Application No: 2005/0196,755

Number of patents in Portfolio can not be more than 2000

In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells

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Abstract

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The present invention relates to a high efficiency method of expressing immunoglobulin molecules in eukaryotic cells. The invention is further drawn to a method of producing immunoglobulin heavy and light chain libraries, particularly using the trimolecular recombination method, for expression in eukaryotic cells. The invention further provides methods of selecting and screening for antigen-specific immunoglobulin molecules, and antigen-specific fragments thereof. The invention also provides kits for producing, screening and selecting antigen-specific immunoglobulin molecules. Finally, the invention provides immunoglobulin molecules, and antigen-specific fragments thereof, produced by the methods provided herein.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
UNIVERSITY OF ROCHESTERROCHESTER, NY591

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Smith, Ernest S Ontario, NY 38 151
Zauderer, Maurice Pittsford, NY 51 241

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
UNIVERSITY OF ROCHESTER (7)
7,858,559 In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells 1 2001
7,563,882 Polynucleotides encoding antibodies that bind to the C35 polypeptide 18 2003
8,741,810 In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells 0 2007
7,750,125 Antibodies that bind to the C35 polypeptide 13 2007
7,968,688 Antibodies that bind to the C35 polypeptide 0 2009
7,879,990 Polynucleotides encoding antibodies that bind to the C35 polypeptide 0 2009
7,910,551 Gene differentially expressed in breast and bladder cancer and encoded polypeptides 0 2009
 
4-ANTIBODY AG (3)
7,741,077 Method for the generation of genetically modified vertebrate precursor lymphocytes and use thereof for the production of heterologous binding proteins 1 2001
8,748,353 Identification of antigen or ligand-specific binding proteins 0 2009
8,716,194 Identification of antigen or ligand-specific binding proteins 0 2011
 
ABBVIE BIOTHERAPEUTICS INC. (3)
7,947,495 Immunoglobulin display vectors 1 2008
8,633,139 Methods of screening complex protein libraries to identify altered properties 0 2008
8,283,170 Immunoglobulin display vectors 0 2011
 
CRUCELL HOLLAND B.V. (3)
8,642,513 Method for preparing immunoglobulin libraries 0 2006
8,211,431 Human binding molecules having killing activity against staphylococci and uses thereof 0 2007
8,460,666 Human binding molecules having killing activity against staphylococci and uses thereof 0 2012
 
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (3)
7,465,787 Yeast cell surface display of proteins and uses thereof 4 2003
7,569,357 High affinity TCR proteins and methods 2 2004
8,372,636 Yeast cell surface display of proteins and uses thereof 0 2008
 
VACCINEX, INC. (2)
7,919,095 Anti-IL-6 monoclonal antibodies 0 2007
8,637,026 Anti-C35 antibody combination therapies and methods 0 2008
 
AMGEN INC. (1)
7,884,054 Methods for identifying functional antibodies 1 2004
 
JANSSEN BIOTECH, INC. (1)
8,663,980 Vectors, host cells, and methods of production and uses 0 2008
 
MEDICAL UNIVERSITY OF SOUTH CAROLINA (1)
8,715,743 Human monoclonal antibodies and methods for producing the same 0 2008