Method of drug delivery through selective targeting, of biological tissues containing populations of receptor proteins, with novel conjugate molecules
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United States of America Patent
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Issued Date -
Sep 15, 2005
app pub date -
Dec 29, 2004
filing date -
Apr 26, 2002
priority date (Note) -
Abandoned
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Abstract
The present invention provides a method of novel drug delivery through selective targeting of biological tissues containing populations of MOR or SPR proteins by the administration of novel chimeric hybrid molecules. The method is illustrated by administration of a novel chimeric hybrid molecule containing an opioid moiety of chemically modified morphine (3) that binds to and activates the human mu (.mu.) opioid receptor, with the opioid moiety linked through a novel linker-hinge (4) to a substance P peptide fragment moiety (5) that binds to and activates the human substance P receptor.
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