Medical articles having regions with polyelectrolyte multilayer coatings for regulating drug release
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United States of America Patent
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Jun 29, 2010
Grant Date -
Sep 22, 2005
app pub date -
Mar 19, 2004
filing date -
Mar 19, 2004
priority date (Note) -
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status (Latency Note)
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Abstract
The medical articles which including the following: (a) a ceramic or metallic region whose surface includes a plurality of depressions, (b) a multilayer coating region including multiple polyelectrolyte layers deposited over the surface of the ceramic or metallic region; and (c) a therapeutic agent disposed beneath or within the multilayer coating region. According to another aspect of the present invention, medical articles are provided, which include: (a) a ceramic or metallic region, (b) a multilayer coating region including multiple polyelectrolyte layers deposited over a surface of the ceramic or metallic region, the multilayer coating region including a plurality of protuberances; and (c) a therapeutic agent disposed within regions beneath the protuberances. Also described herein are methods of making such medical articles, and methods of administering a therapeutic agent to a patent using such medical articles.
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