Treatment of rheumatoid arthritis with FLIP antagonists
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United States of America Patent
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Issued Date -
Sep 22, 2005
app pub date -
Nov 1, 2004
filing date -
Oct 30, 2003
priority date (Note) -
Abandoned
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Abstract
The invention encompasses novel methods of treating rheumatoid arthritis and its symptoms and novel methods of identifying and screening for drugs useful in the treatment of rheumatoid arthritis and its clinical symptoms. Targeted manipulation of a computer model of a human rheumatic joint provided the surprising result that decreasing the activity of FLIP, an inhibitor of apoptosis, by at least 25% has a significant impact on the pathophysiology of rheumatoid arthritis. Inhibition of the activity of FLIP by at least 25% is predicted to alleviate the symptoms of rheumatoid arthritis.
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