Combination of transplantation and oncolytic virus treatment
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United States of America Patent
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app pub date -
Mar 10, 2005
filing date -
Mar 12, 2004
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Abstract
Oncolytic viruses can be used to purge cellular compositions to remove undesired neoplastic cells before the cellular compositions are used for transplantation. The present invention relates to the use of a virus to pre-treat a subject prior to delivery into the subject a transplant that has been purged with the same virus. This pre-treatment serves to elicit an immune response in the subject against the virus, thereby protecting the subject from infections by the virus after receiving the transplant, which likely contains infectious viruses.
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