Cross-linked hyaluronate compounds
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United States of America Patent
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Issued Date -
Oct 6, 2005
app pub date -
May 4, 2005
filing date -
Apr 17, 2002
priority date (Note) -
Abandoned
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Abstract
1 There is disclosed a cross-linked hyaluronate compound obtained by reacting a sodium hyaluronate compound with a polfunctional aziridine compound as a cross-linking agent. The polyfunctional aziridine compound was added to hyaluronan of various molecular weights in an equivalent ratio of HA/AZ of 1:1 to 1:10, preferably, 1:3 to 1:10, more preferably, 1:3 to 1:5; most preferably 1:4 to 1:5. The polymeric hydrogel compounds obtained are useful to prevent the formation of post-operative adhesions, designing tissue engineering applications, and the like.
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