Nucleic acid vaccine compositions having a mammalian CD80/CD86 gene promoter driving antigen expression
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United States of America Patent
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Issued Date -
Oct 13, 2005
app pub date -
Dec 31, 2003
filing date -
Nov 3, 1999
priority date (Note) -
Abandoned
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Abstract
Polynucleotides encoding at least one immunizing antigen whose expression is controlled by a promoter derived from a gene encoding a co-stimulatory molecule are provided. The polynucleotides may also encode adjuvants. Compositions comprising at least one immunizing agent and at least one cytokine that enhance dendritic cell stimulation and/or survival are also provided. Methods for eliciting an immune response against the immunizing agent are also provided. The method includes the steps of administering the polynucleotides and, optionally, co-administering an adjuvant.
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