Enzyme-free isothermal exponential amplification of nucleic acids and nucleic acid analog signals

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United States of America Patent

PATENT NO 7538202
APP PUB NO 20050227259A1
SERIAL NO

11009386

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Abstract

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An enzyme-free, isothermal method of generating an amplification signal indicative of a target nucleic acid molecule is provided, as are compositions for performing such a method. An advantage of the detection system is that it is very sensitive, and can allow for the detection of a single target molecule in a sample.

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Patent Owner(s)

  • CALIFORNIA INSTITUTE OF TECHNOLOGY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Winfree, Erik Altadena, US 6 220
Yurke, Bernard Plainfield, US 34 420
Zhang, David Overland Park, US 80 750

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