Enhancement of ampakine-Induced facilitation of synaptic responses by cholinesterase inhibitors
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United States of America Patent
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Issued Date -
Oct 13, 2005
app pub date -
Jan 26, 2005
filing date -
Jan 26, 2004
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Abstract
The present invention relates to a method for enhancing the physiological and therapeutic effects of an AMPA receptor potentiator in an animal by co-administration of an acetylcholinesterase inhibitor with the potentiator. Also disclosed is a method for treating a cognitive disorder in an animal by co-administration of an AMPA receptor potentiator and an acetylcholinesterase inhibitor. In addition, a composition comprising an effective amount of an AMPA receptor potentiator and an effective amount of an acetylcholinesterase inhibitor is also disclosed.
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